I came across this L.A. Times' list of the top 25 movies set in Los Angeles. It's hard to argue against flicks like Who Killed Roger Rabbit?, To Live and Die in L.A., and Fletch.
But no Ruthless People? C'mon, it's got everything L.A., like celebrity/rich-obsessed cops, fashion industry wannabes, diet fads, and a cynical view of Angelenos . . . .